Driving Simulator Motion Cueing Assessment: A Platform Design Perspective

The overall aim of this thesis was to study the effects of a simulator’s motion system on vestibular motion cueing fidelity in different contexts, evaluated in terms of drivers’ perception and behaviour, in low and high road friction conditions. The effects of manipulating the motion cueing algorithm (MCA), was found to be a function of the vehicle motion in a manoeuvre, and significant effects were observed. The applicability of simulators for the assessment of vehicle driven attribute qualities such as ride, steering and handling were studied by manipulating vehicle ride height (RH). The differences between the RHs were subjectively distinguishable by the drivers in the simulator. Incongruities between the subjective preferences and objective performances were observed in both of the independent comparisons of the MCAs and RHs. The effects of motion platform (MP) workspace size were found to be dependent on the manoeuvres and road friction level. In the low-friction condition, with the increase of MP size, two opposite effects were observed on drivers’ preferences and their performances, depending on the manoeuvre. In high-friction, in most of the handling and steering qualities, a direct relation was found between the MP size and appropriate vehicle RH. Furthermore, the optimal tuning of the MCAs and optimisation of the MP workspace size was introduced. A conservative motion cueing fidelity criteria was defined. A multi-layered optimisation method was developed that uses the optimal setting of the MCA, to address the MP translational workspace size, and to meet the fidelity criteria; applicable for different manoeuvres. This method was tested on the drivers’ performance data collected from the experiments in the simulator

Electrochemiluminesence Epidemiologic Detection of Toxoplasma gondii Infection in Pregnant Women With Direct and Indirect Diagnostic Techniques (ELISA Avidity Plus Biochemical Assay)

Background and aims: Toxoplasmosis is a very common disease in the world. Two types of acquired toxoplasmosis have been detected. In the chronic toxoplasmosis, the abnormality of tissue function is little but, in acute toxoplasmosis, function of RES system becomes interrupted. The assessment of toxoplasma antibody with tissue enzymes in this stage is very important. Furthermore, serum ferritin in some conditions became high in acute phase of infectious disease. Methods: This study was based on comparative abundance study. Materials consisted of 980 serum and amniotic fluid samples collected from human blood with high level of IgG antibody against Toxoplasma gondii in Rajaie center, Tehran, Iran. The standard test was ELISA assay to detect these antibodies and the main test was measurement of liver transaminases (SGOT, SGPT) bilirubin and ferritin to evaluate acute toxoplasmosis. Data analysis was done by SPSS version 18.0. This study was done during March to June, 2017. Results: Results showed that in some patients with high level of IgG AVIDITY antibody against T. gondii the level of liver transaminases, serum bilirubin and ferritin became increased. For example in 120 patients with acute toxoplasmosis the mean serum levels of SGOT were 108 IU/L and in 80 patients the mean serum bilirubin were about 5 mg/dL. Conclusion: In acute congenital toxoplasmosis, the evaluation of IgG AVIDITY was first step and then the measurement of biochemical factors such as serum transaminases, serum Bilirubin and serum Ferritin were important

Bronchial wall necrosis secondary to mucormycosis following SARS-Cov2 infection: A case report

Coronavirus 2019 infection (COVID-19) has a broad spectrum of clinical complications, some unrecognized. Herein, a case of a diabetic patient with multiple episodes of hemoptysis 2 months following her recovery from SARS-CoV-2 infection is reported. The initial computed tomography (CT scan) revealed the left lower lobe collapsed secondary to bronchial narrowing and obliteration. Bronchoscopy was performed, indicating necrotic endobronchial tissue, which was confirmed histopathologically as invasive mucormycosis. Bronchial necrosis due to mucormycosis is an unusual presentation of COVID-19-associated pulmonary mucormycosis. The accurate diagnosis could be challenging as it can resemble other pathologies such as malignancies. Therefore, it is crucial to identify this fatal complication in patients with prolonged COVID-19 and lung collapse